49ers vs. Cardinals Showdown: Who Takes the NFC West Lead?
The San Francisco 49ers and the Arizona Cardinals faced off in a Week 3 NFC West divisional battle at Levi's Stadium. Both teams entered the game with a 2-0 record, hungry to claim sole possession of first place after the Los Angeles Rams' loss.
Key Game Details
The game took place on Sunday, September 21, 2025, kicking off at 4:25 p.m. ET. Fans could watch the game on Fox or stream it via fubo+. The 49ers were favored by 3 points, with an over/under of 43.5 points.
Injury Impact
The 49ers were without key players including QB Brock Purdy, TE George Kittle, and WRs Brandon Aiyuk and Jauan Jennings. However, RB Christian McCaffrey was healthy and ready to contribute. The Cardinals were missing CBs Garrett Williams and Will Johnson, and LT Paris Johnson due to injury.
Quarterback Matchup: Mac Jones vs. Kyler Murray
With Brock Purdy sidelined, Mac Jones took the reins for the 49ers. Jones, aiming to prove himself, showcased his potential. Facing him was Kyler Murray, both quarterbacks under pressure to deliver on their first-round draft potential.
How to Follow the Action
- TV: Fox
- Stream: fubo+
- Radio: KSFO (810 AM), The Bone (107.7 FM), 49ers Radio Network
- Spanish Radio: 49ers App or 49ers.com/esp
What's at Stake?
This game was more than just a Week 3 matchup. It was a chance for either the 49ers or the Cardinals to assert dominance in the NFC West early in the season. The winner would not only move to 3-0 but also gain a crucial advantage in the divisional standings. Stay tuned for post-game analysis and highlights.